Robin Yates Laboratory

Selected Publications

Ewanchuk, B.W., Arnold, C.R., Balce, D.R., Premnath P., Orsetti, T.L., Warren, A.L., Olsen A., Krawetz, R.J. and Yates, R.M. (2021). A non-immunological role for γ-interferon–inducible lysosomal thiol reductase (GILT) in osteoclastic bone resorption. Science Advances. 7:1-11. [view]

Nguyen, J.A. and Yates, R.M. (2021). Better Together: Current Insights Into Phagosome-Lysosome Fusion. Frontiers in Immunology. 12:1-19. [view]

Ewanchuk, B.W. and Yates, R.M. (2018). The phagosome and redox control of antigen processing. Free Radical Biology & Medicine. 125:53-61. [view]

Ewanchuk, B.W., Allan, E.R.O., Warren, A.L., Ramachandran, R., and Yates, R.M. (2018). The cooling compound icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response. The FASEB Journal.32(3):1236-1249. [view]

Allan, E.R.O., Campden, R.I., Ewanchuk, B.W., Tailor, P., Balce, D.R., McKenna, N.T., Greene, C.J., Warren, A.L., Reinheckel, T., and Yates, R.M. (2017). A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis. Journal of Neuroinflammation. 14(1):103. [view]

Cheung, S., Greene, C.J., and Yates, R.M. (2016). Simultaneous analysis of multiple lumenal parameters of individual phagosomes using high-content imaging. Methods in Molecular Biology: Phagocytosis and Phagosomes. 1519:227-239. [view]

Balce, D.R. and Yates, R.M. (2016). Fluorometric approaches to measuring reductive and oxidative events in phagosomes. Methods in Molecular BiologyPhagocytosis and Phagosomes.1519:215-225. [view]

Balce, D.R., Rybicka, J.M., Greene, C.J., Ewanchuk, B.W., and Yates, R.M. (2016). Ligation of FcyR alters phagosomal processing of protein via augmentation of NADPH oxidase activity. Traffic17(7):786-802. [view]

Balce, D.R., Greene, C.J., Tailor, P., and Yates, R.M. (2015). Endogenous and exogenous pathways maintain the reductive capacity of the phagosome. Journal of Leukocyte Biology. 100(1):17-26.[view]

Chaudhuri, S., McKenna, N., Balce, D.R., and Yates, R.M. (2015). Infection of porcine bone marrow-derived macrophages by porcine respiratory and reproductive syndrome virus impairs phagosomal maturation. Journal of General Virology. 97(3):669-79[view]

Allan, E.R.O. and Yates, R.M. (2015). Redundancy between cysteine cathepsins in murine experimental autoimmune encephalomyelitis. PLoS One. 10(6):e0128945. [view]

Balce, D.R., Allan, E.R.O., McKenna, N.T., and Yates, R.M. (2014). Gamma-Interferon-Inducible Lysosomal Thiol Reductase (GILT) Maintains Phagosomal Proteolysis in Alternatively Activated Macrophages. Journal of Biological Chemistry. 289(46):31891-904. [view]

Allan, E.R.O., Tailor, P., Balce, D.R., Pirzadeh, P., McKenna, N.T., Renaux, B., Warren, A.L., Jirik, F.R., and Yates, R.M.(2014). NADPH oxidase modifies patterns of MHC-II-restricted epitopic repertoires through redox control of antigen processing. Journal of Immunology. 192(11):4989-5001. [view]

Balce, D.R. and Yates, R.M. (2013). Redox-sensitive probes for the measurement of redox chemistries within phagosomes of macrophages and dendritic cells. Redox Biology. 1(1):467-474. [view]

Yates, R.M. (2013). Redox considerations in the phagosome: current concepts, controversies, and future challenges. Antioxidants and Redox Signaling18(6):628-9. [view]

Rybicka, J.M., Balce, D.R., Chaudhuri, S., Allan, E.R.O., and Yates, R.M. (2012). Phagosomal proteolysis in dendritic cells is modulated by NADPH oxidase in a pH-independent manner. The EMBO Journal. 31(4):932-44.[view]

Balce, D.R., Li, B., Allan, E.R.O., Rybicka, J.M., Krohn, R.M., and Yates, R.M. (2011). Alternative activation of macrophages by IL-4 enhances the proteolytic capacity of their phagosomes through synergistic mechanisms. Blood118(15):4199-208. [view]

Lemmon, J.C., McFarland, R.J., Rybicka, J.M., Balce, D.R., McKeown, K.R., Krohn, R.M., Matsunaga, T.O., and Yates, R.M. (2011). In vitro and in vivo transfection of primary phagocytes via microbubble-mediated intraphagosomal sonoporation. Journal of Immunological Methods. 371(1-2):152-8. [view]

Rybicka, J.M., Balce, D.R., Khan, M., Krohn, R.M., and Yates, R.M. (2010). NADPH oxidase activity controls phagosomal proteolysis in macrophages through modulation of the lumenal redox environment of phagosomes. Proc Nat Acad Sci USA107(23):10496-501. [view]

VanderVen, B.C., Hermetter, A., Huang, A., Maxfield, F.R., Russell, D.G., and Yates, R.M. (2010). Development of a novel, cell-based chemical screen to identify inhibitors of intraphagosomal lipolysis in macrophages. Cytometry A. 77(8):751-60.

Yates, R.M. and Russell, D.G. (2009). Recording phagosome maturation through the real-time, spectrofluorometric measurement of hydrolytic activities. Methods in Molecular Biology: Macrophages and Dendritic Cells. 531:157-171.

Yates, R.M. and Russell, D.G. (2008). Real-time spectrofluorometric assays for the lumenal environment of the maturing phagosome. Methods in Molecular Biology: Phagosomes and Autophagosomes. 445:311-325.